Abstract
Demethylation of methindione was shown to take place in vivo in rats. The process involves the participation of the microsomal NADPH-dependent electron transport system. In experiments in vivo demethylation of methindione takes place rapidly and is accompanied by the partial loss of its anticonvulsant properties.
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Kiseleva, V.N., Gilev, A.P., Parinov, V.Y. et al. Demethylation of methindione. Bull Exp Biol Med 83, 832–834 (1977). https://doi.org/10.1007/BF00798889
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DOI: https://doi.org/10.1007/BF00798889