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Effect of lithium chloride on ethanol consumption by rats

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Selective consumption of ethanol was produced in rats in the course of 2 months by giving a 5% solution of ethanol as the sole source of fluid. Lithium chloride, given by intraperitoneal injection in a dose of 35 mg/kg twice a day for 14 days, depressed the preference for ethanol by producing reversal of motivations, the mechanism of which is connected with changes in the activity of the hypothalamic centers of neuroendocrine regulation. The possible use of lithium salts in the treatment of chronic alcoholism is discussed.

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Authors and Affiliations

  1. Academy of Medical Sciences of the USSR, USSR

    V. V. Zakusov (Academician)

Authors
  1. V. V. Zakusov
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  2. B. I. Lyubimov
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  3. A. N. Yavorskii
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  4. V. I. Fokin
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Additional information

Laboratory of Pharmacology of the Nervous System and Laboratory of General Pharmacology, Institute of Pharmacology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 6, pp. 693–696, June, 1977.

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Zakusov, V.V., Lyubimov, B.I., Yavorskii, A.N. et al. Effect of lithium chloride on ethanol consumption by rats. Bull Exp Biol Med 83, 823–825 (1977). https://doi.org/10.1007/BF00798885

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  • DOI: https://doi.org/10.1007/BF00798885

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