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Inhibition of cyclic AMP phosphodiesterase of the rat heart and brain by neurohormone C in vitro

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of neurohormone C, a new coronary dilator isolated from bovine hypothalamus, on activity of the phosphodiesterase (PDE) of cyclic adenosine-3′,5′-monophosphate (AMP) was investigated. Considerable inhibition of PDE was shown in the supernatant of rat brain and heart homogenates (2000g) under the influence of neurohormone C. The existence of correlation between the coronary dilator effect of the hormone and regulation of the cyclic AMP level under the influence of a change in PDE activity is postulated.

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Authors
  1. A. A. Galoyan
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  2. B. Ya. Gurvits
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  3. M. A. Pogosyan
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Galoyan, A.A., Gurvits, B.Y. & Pogosyan, M.A. Inhibition of cyclic AMP phosphodiesterase of the rat heart and brain by neurohormone C in vitro. Bull Exp Biol Med 83, 820–822 (1977). https://doi.org/10.1007/BF00798884

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  • DOI: https://doi.org/10.1007/BF00798884

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