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Possible role of prostaglandins A1 and B1 in spasm of the internal carotid arteries

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments were carried out on the internal carotid artery of a dog, isolated from the rest of the circulation and continuously perfused in situ with oxygenated Ringer-Krebs bicarbonate solution. Prostaglandins A1 and B1 (PGA1 and PGB1) cause contraction of the artery. The effect of both prostaglandins was much less, but more prolonged, than the effect of the same doses of serotonin. The following facts are evidence of a possible role of prostaglandins in the development of angiospasm: a) In response to the repeated action of PGA1 and PGB1 their effect is unchanged and it therefore ought probably not to be reduced during the prolonged action of these prostaglandins on the vessel wall; b) PGA1 and PGB1 potentiate the constrictor effect of both serotonin and noradrenalin.

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Authors
  1. G. I. Mchedlishvili
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  2. L. G. Ormotsadze
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Mchedlishvili, G.I., Ormotsadze, L.G. Possible role of prostaglandins A1 and B1 in spasm of the internal carotid arteries. Bull Exp Biol Med 83, 783–785 (1977). https://doi.org/10.1007/BF00798872

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  • DOI: https://doi.org/10.1007/BF00798872

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