Mechanism of disturbance of inhibitory electrogenesis in spinal α-motoneurons in experimental local botulinus poisoning

  • V. V. Mikhailov
  • G. N. Barashkov
Pathological Physiology and General Pathology


The character of changes in postsynaptic inhibition in spinal α-motoneurons of cats was studied in the course of experimental local botulinus poisoning. At the beginning of development of the local paralytic syndrome a marked decrease in the amplitude of the reciprocal, and a smaller decrease in amplitude of the polysynaptic IPSPs was observed. On the appearance of total paralysis of the muscles from botulinus poisoning the reciprocal and polysynaptic IPSPs were inhibited even more, but they never disappeared completely and were never converted into depolarization potentials. During the development of the IPSP the synaptic permeability of the motneurons as a rule was reduced.

Key words

botulinus poisoning spinal motoneurons inhibitory postsynaptic potential 


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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • V. V. Mikhailov
  • G. N. Barashkov

There are no affiliations available

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