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Effect of micropolarization of focal and extrafocal brain structures on experimental epilepsy

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of micropolarization (MP) with a current of 0.05–0.75 μA on epileptogenic foci produced by injection of 500 and 1000 units of penicillin solution into the motor cortex was investigated in chronic experiments on rabbits. A single MP of extrafocal structures (corpus callosum, caudate nucleus) and of the region of the focus was shown to inhibit the development of paroxysmal responses. Repeated MP of the region of the focus had the opposite effect. The effects observed can probably be explained not only by the specific role of the structures studied in the processes of formation and spread of excitation, and by their initial functional state, but also by the dependence of the activity of these structures on the conditions of MP.

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Authors
  1. E. I. Tkachenko
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Tkachenko, E.I. Effect of micropolarization of focal and extrafocal brain structures on experimental epilepsy. Bull Exp Biol Med 83, 765–768 (1977). https://doi.org/10.1007/BF00798866

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  • DOI: https://doi.org/10.1007/BF00798866

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