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Changes in the subcutaneous connective tissue of the rabbit ear in the process of tumor development induced by 9,10-dimethyl-1,2-benzanthracene

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

33 rabbits were used in the experiment, and the carcinogenic treatment employed was painting the ears of rabbits with 1% 9,10-dimethyl-1,2-benzanthracene in benzene 3 times a week. After such treatment, a high incidence of skin tumor was observed. The processes of carcinogenesis in the epithelium of rabbit ear were accompanied by marked alteration of the dermal connective tissue. Lymphocytic infiltration in the derma appeared at an early stage and persisted up to the end of the experiment.

Invasion of dermis by the cancerous epithelium was accompained by marked proliferation of the surrounding connective tissue, in which a great amount of chromotropic mucopolysacchride was found. In the early stage of carcinogenesis the basal membrane of the epithelium was preserved; at a later stage around the invasively growing epithelial zones newly developed basal membranes were observed.

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Authors and Affiliations

  1. Laboratory of Chemical Cancerogenic Substances of the Division for the Study of Cancerogenic Agents of the Institute of Experimental and Clinical Oncology, Akad. Med. Nauk SSSR, Moscow

    Ou Pao-hsiung

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  1. Ou Pao-hsiung
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Pao-hsiung, O. Changes in the subcutaneous connective tissue of the rabbit ear in the process of tumor development induced by 9,10-dimethyl-1,2-benzanthracene. Bull Exp Biol Med 55, 191–193 (1964). https://doi.org/10.1007/BF00798829

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  • DOI: https://doi.org/10.1007/BF00798829

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