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Synthesis of new reagents for the fluorescence derivatisation of thiols and alcohols

Synthese von neuen Reagentien zur Fluoreszenzderivatisierung von Thiolen und Alkoholen

Synthesis of fluorescent dyes, 15

  • Organische Chemie Und Biochemie
  • Published:
Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Abstract

The synthesis of two selective thiol derivatisation reagents (3, 4b) is described, starting from readily available 2-(4-aminophenyl)-6-methyl-benzothiazole (1). The isocyanate6, being a known alcohol derivatisation reagent, is obtained from1 in a two step synthesis, in which the usual isocyanate synthesis using phosgen is avoided.

Zusammenfassung

Die Synthese zweier selektiver Thiolderivatisierungsreagentien (3, 4 b), ausgehend vom leicht zugänglichen 2-(4-Aminophenyl)-6-methylbenzthiazol (1), wird beschrieben. Das Isocyanat6, ein bekanntes Reagens zur Derivatisierung von Alkoholen, wird ebenfalls aus Verbindung1 in zweistufiger Synthese erhalten, bei welcher die Isocyanatsynthese mit Hilfe von Phosgen umgangen wird.

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Authors and Affiliations

  1. Institut für Organische Chemie, Universität Graz, A-8010, Graz, Austria

    Otto S. Wolfbeis & Harry Marhold

Authors
  1. Otto S. Wolfbeis
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  2. Harry Marhold
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Additional information

Presented in part at the First Triannual Symposium on Organic Chemistry (TRISOC 1), April 1982, Trieste, Italy.

This work is dedicated to Prof. Dr.Erwin Schauenstein on the occasion of his 65th birthday.

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Wolfbeis, O.S., Marhold, H. Synthesis of new reagents for the fluorescence derivatisation of thiols and alcohols. Monatsh Chem 114, 599–604 (1983). https://doi.org/10.1007/BF00798615

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  • DOI: https://doi.org/10.1007/BF00798615

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