Abstract
To discover the mechanisms of function of the locus coeruleus (LC), methods of light and electron microscopy were used to study the responses of neurons of this nucleus to experimental asphyxia. Besides specific neuronal effects (taking place either directly through axons of LC cells or indirectly through the brainstem reticular formation), LC was shown to have a humoral effect on the brain structures. Two possible mechanisms of transmission of catecholamines synthesized in the soma of the LC cells into the bloodstream are postulated: through the cell membrane and subsequently through the basement membrane of the capillary and cytoplasm of the endothelial cell, and with the participation of glial elements.
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Belova, T.I., Pal'tsev, M.A. Response of the locus coeruleus to asphyxia. Bull Exp Biol Med 84, 1046–1049 (1977). https://doi.org/10.1007/BF00798543
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DOI: https://doi.org/10.1007/BF00798543