Abstract
The concentrations of α-fetoprotein (α-FP) in the neonatal period until the age of three weeks were determined in mice of different genotypes: CBA, C3H, C57BL/Sc/Sn, BALB/c, CC57W, and AKR, and in athymic nude mice (nu/nu). On the first day the α-FP concentration was 2−10–2−9; on the fifth day, 2−8; on the eighth day, 2−7; on the fifteenth day, 2−4; on the twenty-second day, it was zero. The exceptions were the athymic nude (nu/nu) mice, which had lower α-FP titers: 2−2 on the 15th day. It is concluded that control over α-FP synthesis is not connected with the athymia of the nude mice as such, but with other factors.
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Laboratory of Immunochemistry and Department of Immunology, N. I. Pirogov Second Moscow Medical Institute. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 7, pp. 91–93, July, 1977.
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Vasileiskii, S.S., Petrov, R.V. & Tishner, K.G. Dynamics of the α-fetoprotein content in mice of different genotypes in the neonatal period. Bull Exp Biol Med 84, 1028–1030 (1977). https://doi.org/10.1007/BF00798538
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DOI: https://doi.org/10.1007/BF00798538