Abstract
The histamine-liberating action of MCD-peptide and of mellitin, isolated from bee venom, and of substance 48/80 was studied on isolated rat mast cells. The action of MCD-peptide is similar to that of the noncytotoxic agent 48/80 in the character of the dose-response curves, latent period, and temperature-dependence of histamine liberation. The liberation of histamine induced by MCD-peptide is an energy-dependent process but is independent of cyclic AMP.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
I. S. Gushchin, Immediate Cell Allergy [in Russian], Moscow (1976).
I. S. Gushchin, Patol. Fiziol., No. 1, 32 (1977).
I. S. Gushchin, B. Fredholm, and B. Uvnas, Patol. Fiziol., No. 6, 3 (1975).
B. E. Banks, F. D. Rumjanek, N. M. Sinclair et al., Bull. Inst. Pasteur,74, 137 (1976).
M. E. J. Billingham, Nature (London),245, 163 (1973).
H. Breithaupt and E. Habermann, Arch. Pharmakol. Exp. Path.,261, 262 (1968).
B. Fredholm, I. S. Gushchin (I. S. Guschin), K. Elwin, et al., Biochem. Pharmacol.,25, 1583 (1976).
J. Gauedie, J. M. Hanson, F. D. Rumjanek, et al., Eur. J. Biochem.,61, 369 (1976).
E. Habermann, Science,177, 314 (1972).
P. Harter and U. Weber, Hoppe-Seyler's Z. Pysiol. Chem.,365, 693 (1975).
P. Von Haux, Hoppe-Seyler's Z. Physiol. Chem.,350, 536 (1969).
P. A. Shore, A. Burkhalter, and V. H. Cohn, J. Pharmacol. Exp. Ther.,127, 182 (1959).
Rights and permissions
About this article
Cite this article
Gushchin, I.S., Miroshnikov, A.I. & Martynov, V.I. Character of the histamine-liberating action of MCD-peptide from bee venom. Bull Exp Biol Med 84, 1013–1015 (1977). https://doi.org/10.1007/BF00798533
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00798533