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Activity of kidney tissue enzymes in phenylhydrozine anemia and posttransfusional polycythemia

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Activity of hexokinase, glucose-6-phosphate dehydrogenase, lactate and succinate dehydrogenases, and acid and alkaline phosphatases in kidney tissue was investigated. At the same time the blood supply to the cortex and medulla of the kidneys was studied in rats with phenylhydrazine anemia and posttransfusional polycythemia in order to discover any possible connection between changes in the activity of the above enzymes and the erythropoietin-forming function of the kidneys. The blood supply of the kidneys in rats with phenylhydrazine anemia was sharply reduced, whereas in animals with posttransfusional polycythemia it was considerably increased. No changes were found in enzyme activity in the kidney tissue. The results are evidence that the activity of these enzymes is not a regulating factor in the production of erythropoietin by the kidney.

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Authors
  1. É. B. Levi
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  2. I. K. Klemina
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Levi, É.B., Klemina, I.K. Activity of kidney tissue enzymes in phenylhydrozine anemia and posttransfusional polycythemia. Bull Exp Biol Med 84, 948–950 (1977). https://doi.org/10.1007/BF00798513

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  • DOI: https://doi.org/10.1007/BF00798513

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