Skip to main content
SpringerLink
Log in

Alteration of DNA by hydrogen peroxide

  • Published:
Molecular Biology Reports Aims and scope Submit manuscript

Abstract

DNA is altered by the action of hydrogen peroxide, a ubiquitous body constituent. Formation of damaged species is established by changes in four characteristics of DNA: absorption in the ultraviolet, complexing with histone, adsorption by anion exchange resin and charcoal, binding of silver cations. Damaged species of DNA might lead to impaired function of the organism. Gamma globulin by complexing with DNA is a partial inhibitor of this attack by hydrogen peroxide.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. FriedbergE. C. & HanawaltP. C., 1981. Eds, DNA Repair, vol. 1, part A, Dekker, New York.

    Google Scholar 

  2. BaldwinE., 1967. Dynamic Aspects of Biochemistry, University Press, Cambridge, p. 169.

    Google Scholar 

  3. GenerosoW. M., ShelbyM. D. & deSerresF. J., 1980. Eds., DNA Repair and Mutagenesis in Eukaryotes, Plenum, New York.

    Google Scholar 

  4. GemantA., 1979. Molec. Biol. Rep. 5: 257.

    Google Scholar 

  5. WatersW. A., 1964. Mechanism of Oxidation of Organic Compounds, Methuen, London, p. 40.

    Google Scholar 

  6. WhiteJ. & SpringerT., 1980. Physik. Blätter 36: 144.

    Google Scholar 

  7. DavydovaS. L., 1979. SigelE. Ed., Metal Ions in Biological Systems, vol. 8, Dekker, New York, p. 183.

    Google Scholar 

  8. OrgelL. E., 1973. Nature 243: 441.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Wayne State University, Detroit, MI, USA

    A. Gemant

Authors
  1. A. Gemant
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gemant, A. Alteration of DNA by hydrogen peroxide. Mol Biol Rep 8, 21–24 (1981). https://doi.org/10.1007/BF00798380

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00798380

Keywords

Search

Navigation