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Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease

Pediatric Cardiology volume 15, pages 263–267 (1994)Cite this article

Summary

Dipyridamole has been widely used in Japan to treat patients with a coronary aneurysm resulting from Kawasaki disease, but its effect in these patients has not been established. In the present study we assessed the effect of dipyridamole on the coronary arteries of patients with a history of Kawasaki disease by measuring the diameter of the coronary arteries and by quantifying the disappearance time of contrast medium (runoff time) on coronary angiography. Intravenous injection of dipyridamole increased the diameter of nondilated arteries by 7.9%. Its effect on the diameter of dilated coronary arteries (coronary aneurysm) was less than 3% (p<0.01). Runoff time of dilated coronary arteries was significantly (p<0.01) greater than that of nondilated coronary arteries. Dipyridamole accelerated runoff time not only in nondilated coronary arteries (p<0.01) but also in coronary arteries with various degrees of dilatation (p<0.01). We conclude that dipyridamole increases blood flow in coronary arteries without dilating the proximal aneurysm in children with a history of Kawasaki disease.

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Affiliations

  1. Department of Pediatrics, Gunma University School of Medicine, 3-39-15 Showa-machi, 371, Maebashi, Gunma, Japan

    Tomio Kobayashi

  2. Gunma Children's Medical Center, 3-39-15 Showa-machi, 371, Maebashi, Gunma, Japan

    Katsuhiko Sone

Authors
  1. Tomio Kobayashi
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  2. Katsuhiko Sone
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Kobayashi, T., Sone, K. Effect of dipyridamole on the blood flow in coronary aneurysms resulting from Kawasaki disease. Pediatr Cardiol 15, 263–267 (1994). https://doi.org/10.1007/BF00798118

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  • DOI: https://doi.org/10.1007/BF00798118

Key Words

  • Coronary aneurysm
  • Dilatation ratio
  • Dipyridamole
  • Kawasaki disease
  • Runoff time