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Bulletin of Experimental Biology and Medicine

, Volume 81, Issue 4, pp 552–554 | Cite as

Abolition of allogeneic inhibition of hematopoietic stem cells by treatment of recipient mice with cyclophosphamide

  • I. N. Golovistikov
Microbiology and Immunology
  • 18 Downloads

Abstract

After transplantation of bone marrow from C57BL/6 mice into lethally irradiated (CBA x C57BL/6)F1 hybrids, the degree of allogeneic inhibition of the stem cells was 92.5%. Cyclophosphamide, given to the recipients in a dose 200 mg/kg 24h before bone marrow transplantation (4 h after irradiation) reduced the degree of allogeneic inhibition to 24%. Administration of a similar dose of cyclophosphamide did not affect the number of colonies in the spleen of lethally irradiated syngeneic recipients. It is postulated that cyclophosphamide, if injected into lethally irradiated recipients acts on the population of the recipient's radioresistant cells, which are responsible for allogeneic inhibition of the stem cells.

Key Words

allogeneic inhibition hematopoietic stem cells cyclophosphamide 

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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • I. N. Golovistikov

There are no affiliations available

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