Role of thyroid hormones in the mechanism of action of diphtheria toxin on oxidative phosphorylation in rabbit liver mitochondria
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In rabbits with experimental hypothyroidism the ability of the liver mitochondria to carry out oxidative phosphorylation was undisturbed after intravenous injection of diphtheria toxin. In rabbits with experimental hyperthyroidism, the sensitivity of the liver mitochondria to the uncoupling action of diphtheria toxin was sharply increased. It is postulated that the endocrine function of the thyroid gland plays an essential role in the uncoupling action of diphtheria toxin on oxidative phosphorylation.
Key Wordsthyrotoxicosis hypothyroidism diphtheria toxin oxidative phosphorylation
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