Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 81, Issue 4, pp 513–515 | Cite as

Role of thyroid hormones in the mechanism of action of diphtheria toxin on oxidative phosphorylation in rabbit liver mitochondria

  • G. M. Medvedeva
  • L. I. Niselovskaya
Biochemistry and Biophysics
  • 21 Downloads

Abstract

In rabbits with experimental hypothyroidism the ability of the liver mitochondria to carry out oxidative phosphorylation was undisturbed after intravenous injection of diphtheria toxin. In rabbits with experimental hyperthyroidism, the sensitivity of the liver mitochondria to the uncoupling action of diphtheria toxin was sharply increased. It is postulated that the endocrine function of the thyroid gland plays an essential role in the uncoupling action of diphtheria toxin on oxidative phosphorylation.

Key Words

thyrotoxicosis hypothyroidism diphtheria toxin oxidative phosphorylation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    L. I. Niselovskaya and E. M. Paderina, Vopr. Med. Khim., No. 3, 256 (1963).Google Scholar
  2. 2.
    G. I. Medvedeva, Biokhimiya, No. 4, 741 (1969).Google Scholar
  3. 3.
    G. I. Medvedeva and L. I. Niselovskaya, Byull. Éksp. Biol. Med., No. 8, 42 (1973).Google Scholar
  4. 4.
    G. I. Medvedeva and L. I. Niselovskaya, Probl. Éndokrinol., No. 4, 63 (1974).Google Scholar
  5. 5.
    E. L. Hoch, J. Biol. Chem.,241, 524 (1966).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • G. M. Medvedeva
  • L. I. Niselovskaya

There are no affiliations available

Personalised recommendations