Basic Research in Cardiology

, Volume 92, Supplement 2, pp 34–36 | Cite as

Ischemic preconditioning of the heart

  • D. Th. Kremastinos


Public Health Ischemic Precondition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Baxter GF, Marber MS, Patel VC, Yellon DM (1994) Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning. Circulation 90:2993–3000Google Scholar
  2. 2.
    Bolli R (1996) The early and late phases of preconditioning against myocardial stunning and the essential role of oxyradicals in the late phase: an overview. Basic Res Cardiol 91:57–63Google Scholar
  3. 3.
    Cave AC, Collis CS, Downey JM, Hearse DJ (1993) Improved functional recovery by ischemic preconditioning is not mediated by adenosine in the globally ischemic isolated rat heart. Cardiovasc Res 27:663–668Google Scholar
  4. 4.
    Deutsch E, Berger M, Kussmaul WG, Hirshfeld JW, Hermann HC, Laskey WK (1990) Adaptation to ischemia during percutaneous transluminal coronary angioplasty. Circulation 82:2044–2051Google Scholar
  5. 5.
    Iliodromitis EK, Papadopoulos C, Paraskevaidis IA, Kyriakides ZS, Flessa C, Kremastinos D Th (1996) Protection from preconditioning can be reinstated at various reperfusion intervals. Cardiovasc Drugs Ther 10:341–346Google Scholar
  6. 6.
    Iliodromitis EK, Kremastinos D Th, Katritsis DG, Papadopoulos CC, Hearse DJ (1997) Multiple cycles of preconditioning cause loss of protection in open-chest rabbits. J Mol Cell Cardiol 29 (3):915–920Google Scholar
  7. 7.
    Iliodromitis EK, Miki T, Downey JM, Kremastinos D Th (1997) PKC is downstream of adenosine receptors in ischemic preconditioning. Abstract—XIX European Congress of Cardiology, Stockholm, SwedenGoogle Scholar
  8. 8.
    Kloner RA, Shook T, Przyklenk K et al. (1995) Previous angina alters in-hospital outcome in TIMI 4. A clinical correlate to preconditioning? Circulation 91:37–47Google Scholar
  9. 9.
    Li GC, Vasquez JA, Gallagher KP, Lucchesi BR (1990) Myocardial protection with preconditioning. Circulation 82:609–619Google Scholar
  10. 10.
    Li Y, Kloner A (1994) Cardioprotective effects of ischemic preconditioning can be recaptured after they are lost. J Am Coll Cardiol 23:470–474Google Scholar
  11. 11.
    Liu GS, Thornton J, Van Winkle DM et al. (1991) Protection against infarction afforded by preconditioning is mediated by Al adenosine receptors in rabbit heart. Circulation 84:350–356Google Scholar
  12. 12.
    Ottani F, Galvani M, Ferrini D, Sorbello F, Limonetti P, Pantoli D, Rusticali F (1995) Prodromal anginal limits infarct size. A role for ischemic preconditioning. Circulation 91:291–297Google Scholar
  13. 13.
    Parratt JR (1995) Possibilities for the pharmacological exploitation of ischemic preconditioning. J Mol Cell Cardiol 27:991–1000Google Scholar
  14. 14.
    Sack S, Mohri M, Arras M, Schwarz ER, Schaper W (1993) Ischemic preconditioning-time course of renewal in the pig. Cardiovasc Res 27:551–555Google Scholar
  15. 15.
    Vahlhaus C, Schulz R, Post H, Onallah R, Heusch G (1996) No prevention of ischemic preconditioning by the protein kinase C inhibitor staurosporine in swine. Circ Res 79:407–414Google Scholar
  16. 16.
    Vogt AM, Htun P, Arras M, Podzuweit T, Schaper W (1996) Intramyocardial infusion of tool drugs for the study of molecular mechanisms in ischemic preconditioning. Bas Res Cardiol 91:389–400Google Scholar
  17. 17.
    Yellon DM, Alkhulaifi AM, Pugsley WB (1993) Preconditioning the human myocardium. Lancet 342:276–77Google Scholar

Copyright information

© Steinkopff-Verlag 1997

Authors and Affiliations

  • D. Th. Kremastinos
    • 1
  1. 1.2nd Department of CardiologyOnassis Cardiac Surgery CenterAthensGreece

Personalised recommendations