Skip to main content
SpringerLink
Log in

Therapy of myocardial stunning

  • Published:
Basic Research in Cardiology Aims and scope Submit manuscript

Conclusion

Since in the clinical setting stunning may coexist with persistently ischemic and infarcting myocardium, the ben fit el therapeutic interventions on the stunned myocardium must be weighed against potential deleterious effects on the ischemic myocardium.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ambrosio G, Jacobus WE, Bergmann CA, Weisman HF, Becker LC (1987) Preserved high energy phosphate metabolic reserve in globally stunned hearts despite reduction of basal ATP content and contractility. J Mol Cell Cardiol 19: 953–964

    Google Scholar 

  2. Ambrosio G, Weisfeldt M, Jacobus W, Flaherty J (1987) Evidence for a reversible oxygen radical-mediated component of reperfusion injury: reduction by recombinant human superoxide dismutase administered at the time of reflow. Circulation 75: 282–291

    Google Scholar 

  3. Bolli R (1995) Common methodological problems and artifacts associated with studies of myocardial stunning. Basic Res Cardiol 90: 257–262

    Google Scholar 

  4. Bolli R (1991) Superexide dismutase 10 years later: a drug in search of a use. J Am Coll Cardiol 18: 231–233

    Google Scholar 

  5. Bolli R, Zhu W-X, Myers ML, Hartley CJ, Roberts R (1985) Beta-adrenergic stimulation reverses postischemic myocardial dysfunction without producing subsequent deterioration. Am J Cardiol 56: 964–968

    Google Scholar 

  6. Du Toit EF, Opie LH (1992) Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at the onset of reperfusion. Circ Res 70: 960–967

    Google Scholar 

  7. Ehring T, Baumgart D, Krajcar M, Hümmelgen M, Kompa S, Heusch G (1994) Attenuation of myocardial stunning by the ACE-inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins, but not nitric oxide. Circulation 90: 1368–1385

    Google Scholar 

  8. Ehring T, Böhm M, Heusch G (1992) The calcium antagonist nisoldipine improves the functional recovery of reperfused myocardium only when given before ischemia. J Cardiovasc Pharmacol 20: 63–74

    Google Scholar 

  9. Ferrari R, Curello S, Ceconi C, Cargnoni A, Pasini E, Visioli O (1993) Cardioprotection by nisoldipine: role of timing of administration. Eur Heart J 14: 1258–1272

    Google Scholar 

  10. Flaherty JT, Pitt B, Gruber JW, Heuser RR, Rothbaum DA, Burwell LR, George BS, Kereiakes DJ, Deitchman D, Gustafson N, Brinker JA, Becker LC, Mancini GBJ, Topol E, Werns SW (1994) Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction. Circulation 89: 1982–1991

    Google Scholar 

  11. Görge G, Papageorgiou I, Lerch R (1990) Epinephrine-stimulated contractile and metabolic reserve in postischemic rat myocardium. Basic Res Cardiol 85: 595–605

    Google Scholar 

  12. Heusch G (1996) How should stunning be treated? Dial Cardiovasc Med 1: 35–39

    Google Scholar 

  13. Heusch G (1992) Myocardial stunning: a role for calcium antagonists during ischaemia? Cardiovasc Res 26: 14–19

    Google Scholar 

  14. Jeroudi MO, Triana FJ, Patel BS, Bolli R (1990) Effects of superoxide dismutase and catalase, given separately, on myocardial stunning. Am J Physiol 259: H889-H901

    Google Scholar 

  15. Przyklenk K, Kloner RA (1987) Acute effects of hydralazine and enalapril on contractile function of postischemic “stunned” myocardium. Am J Cardiol 60: 934–936

    Google Scholar 

  16. Przyklenk K, Kloner RA (1991) Calcium antagonists and stunned myocardium: importance for clinician? Cardiovasc Drugs Ther 5: 947–952

    Google Scholar 

  17. Qui Y, Galinases M, Ferrari R, Cargnoni A, Ezrin A, Hearse DJ (1992) PEG-SOD improves postischemic functional recovery and antioxidant status in blood-perfused rabbit hearts. Am J Physiol 263: H1243-H1249

    Google Scholar 

  18. Qui Y, Hearse DJ (1992) Comparison of ischemic vulnerability and responsiveness to cardioplegic protection in crystalloid-perfused versus blood-perfused hearts. J Thorac Cardiovasc Surg 103: 960–968

    Google Scholar 

  19. Schäfer S, Linder C, Heusch G (1990) Xamoterol recruits an inotropic reserve in the acutely failing, reperfused canine myocardium without detrimental effects on its subsequent recovery. Naunyn Schmiedebergs Arch Pharmacol 342: 206–213

    Google Scholar 

  20. Schulz R, Guth BD, Pieper K, Martin C, Heusch G (1992) Recruitment of an inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery: a model of short-term hibernation. Circ Res 70: 1282–1295

    Google Scholar 

  21. Schulz R, Rose J, Martin C, Brodde OE, Heusch G (1993) Development of short-term myocardial hibernation: its limitation by the severity of ischemia and inotropic stimulation. Circulation 88: 684–695

    Google Scholar 

  22. Sheiban I, Tonni S, Benussi P, Martini A, Trevi GP (1993) Left ventricular dysfunction following transient ischaemia induced by transluminal coronary angioplasty. Beneficial effects of calcium antagonists against post-ischaemic myocardial stunning. Eur Heart J 14 (Suppl A): 14–21

    Google Scholar 

  23. Sheiban I, Tonni S, Chizzoni A, Marini A, Trevi G (1997) Recovery of left ventricular function following early reperfusion in acute myocardial infarction: a potential role of the calcium antagonist nisoldipine. Cardiovasc Drugs Ther 11: 5–16

    Google Scholar 

  24. Triana JF, Li X-Y, Jamaluddin U, Thornby JI, Bolli R (1991) Postischemic myocardial “stunning”: Identification of major differences between the open-chest and the conscious dog and evaluation of the oxygen radical hypothesis in the conscious dog. Circ Res 69: 731–747

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung für Pathophysiologie Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Germany

    G. Heusch

Authors
  1. G. Heusch
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heusch, G. Therapy of myocardial stunning. Basic Res Cardiol 92 (Suppl 2), 30–31 (1997). https://doi.org/10.1007/BF00797202

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00797202

Keywords

Search

Navigation