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Can we distinguish clinically hibernation from stunning and does it matter?

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References

  1. Afridi I, Kleiman N, Raizner A, Zoghbi W (1995) Dobutamine echocardiography in myocardial hibernation: optimal dose and accurancy in predicting recovery of ventricular function after coronary angioplasty. Circulation 91: 663–670

    Google Scholar 

  2. Ambrosio G, Losi M, Perrone Filardi P, Betocchi S, Pace L, Soricelli A, Piscione F, Salvatore M, Chiariello M, Weiss JL (1993) Resistence of contractile impairment in the absence of flow abnormalities after exercise: evidence for myocardial stunning in patients with stable angina. Circulation 88 (suppl I): I-646. Abstract

    Google Scholar 

  3. Bolli R (1992) Myocardial “stunning” in man. Circulation 86: 1671–1691

    Google Scholar 

  4. Bonow R (1996) Identification of viable myocardium. Circulation 94: 2674–2680

    Google Scholar 

  5. Bonow R (1995) The hibernating myocardium: implications for management of congestive heart failure. Am J Cardiol 75: 17a-25a

    Google Scholar 

  6. Braunwald E, Kloner RAT (1982) The stunned myocardium: prolonged postischaemic ventricular dysfunction. Circulation 66: 1146–1149

    Google Scholar 

  7. Conversano A, Walsh J, Geltman E Perez J, Bergmann S, Gropler R (1996) Delineation of myocardial stunning and hibernation by positron emission tomography in advanced coronary artery disease. Am Heart J 131: 440–450

    Google Scholar 

  8. De Zwaan C, Cheriex E, Braat S, Stappers J, Wellens H (1991) Improvement of systolic and diastolic left ventricular wall motion by serial echocardiograms in selected patients treated for unstable angina. Am Heart J 121: 789–797

    Google Scholar 

  9. Dilsizian V, Bonow R (1993) Current diagnostic techniques of assessing myocardial viability in patients with hibernating and stunned myocardium. Circulation 87: 1–20

    Google Scholar 

  10. Ferrari R, Alfieri O, Curello S, Ceconi C, Cargnoni A, Marzollo P, Pardini A, Caradonna E, Visioli O (1990) Occurrence of oxidative stress during reperfusion of the human heart. Circulation 81: 201–211

    Google Scholar 

  11. Gorge G, Papageorgiu I, Lerch R (1990) Epinephrine-stimulated contractile and metabolic reserve in postischem cardium. Basic Res Cardiol 85: 595–605

    Google Scholar 

  12. Indolfi C, Piscione F, Perrone-Filardi P, Prastaro M, Di Lorenzo E, Saccà L, Salvatore M, Condorelli M, Chiariello M (1996) Inotropic stimulation by dobutamine increases left ventricular regional function at the expense of metabolism in hibernating myocardium. Am Heart J 132: 542–549

    Google Scholar 

  13. Ito H, Tomooka T, Sakai N, Higashino Y, Fujii K, Masuama T, Kitabatake A, Minamino T (1993) Time-course of functional improvement in stunned myocardium in risk area in patients with reperfused anterior infarction. Circulation 87: 355–362

    Google Scholar 

  14. Jeroudi M, Cheirif J, Habib G, Bolli R (1994) Prolonged wall motion abnormalities chest pain at rest in patients with unstable angina: a possible manifestation of myocardial stunning. Am Heart J 127: 1241–1250

    Google Scholar 

  15. La Canna G, Alfieri O, Giubbini R, Gargano M, Ferrari R, Visioli O (1994) Echocardiography during infusion of dobutamine for identification of reversible dysfunction in patients with chronic coronary artery disease. J Am Coll Cardiol 23: 617–626

    Google Scholar 

  16. Maddahi J, Ganz W, Ninomiya K, Hashida J, Fishbein M, Mondrar A, Buchbinder N, Marcus H, Geft I, Shah PK, Rozanski A, Swan H, Berman D (1981) Myocardial savage by intracoronary thrombolysis in evolving acute myocardial infarction: evaluation using intracoronary injection of thallium-201. Am Heart J 102: 664–674

    Google Scholar 

  17. Nitzsche EU, Choi Y, Czernin J, Hoh CK, Huang SC, Schelbert HR (1996) Noninvasive quantification of myocardial blood flow in humans. Circulation 93: 2000–2006

    Google Scholar 

  18. Nixon Jv, Brown C, Smitherman TC (1982) Identification of transient and persistent segmental wall motion abnormalities in patients with unstable angina by two-dimensional echocardiography. Circulation 65: 1497–1503

    Google Scholar 

  19. Rahimtoola Sh, Griffith GC (1989) The hibernating myocardium. Am Heart J 117: 211–221

    Google Scholar 

  20. Rahimtoola Sh (1996) Hibernating myocardium has reduced blood flow at rest that increases with low-dose dobutamine. Circulation 94: 3055–3061

    Google Scholar 

  21. Rahimtoola Sh (1985) A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulation 72: v123-v135

    Google Scholar 

  22. Robertson W, Feingenbaum H, Armstrong W, Dillon J, O'Donnell R, Mc Henry P (1983) Exercise echocardiography: a clinical practical addition in the evaluation of coronary artery disease. J Am Coll Cardiol 6: 1085–1089

    Google Scholar 

  23. Sawada S, Elsner G, Segar D, O'Shaughnessy M, Rhouri S, Foltz J, Boudrillon P, Bates J, Fineberg N, Ryan T, Hutchins G, Feigenbaum H (1997) Evaluation of patterns of perfusion and metabolism in dobutamine-responsive. Myocardium J Am Coll Cardiol 29: 55–61

    Google Scholar 

  24. Schulz R, Guth B, Pieper K, Martin C, Heusch G (1992) Recruitment of an Inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery: a model of short-term hibernation. Circ Res 70: 1282–1295

    Google Scholar 

  25. Schulz R, Rose J, Martin C, Brodde O, Heusch G (1993) Development of shortterm myocardial hibernation: its limitation by the severity of ischemia and inotropic stimulation. Circulation 88: 684–695

    Google Scholar 

  26. Sheiban I, Tonni S, Benussi P, Marini A, Trevi GP (1993) Left ventricula dysfunction following transient ischemia induced by trans-luminal coronary angioplasty. Beneficial effects of calcium antagonists against post-ischemic myocardial stunning. Eur Heart J 14 (suppl A): 14–21

    Google Scholar 

  27. Smart SC, Sawada S, Ryan T, Segar D, Atheron L, Berkovitz K, Bourdillon PD, Feigenbaum H (1993) Low-dose dobutamine echocardiography detects reversible dysfunction after thrombolytic therapy of acute myocardial infarction. Circulation 88: 405–415

    Google Scholar 

  28. Tillisch J, Brunken R, Marshall R, Schwaiger M, Mandelkern M, Phelps M, Schelbert H (1986) Reversibility of cardiac wallmotion abnormalities predicted by positron tomography. N Engl J Med 314: 884–888

    Google Scholar 

  29. Vanoverschelde J, Wijins W, Deprè C, Essamri B, Heyndrickx GR, Borgers M, Bol A, Melin JA (1993) Mechanisms of chronic regional postischemic dysfunction in humans new insights from the study of noninfarcted collateral-dependent myocardium. Circulation 87: 1513–1523

    Google Scholar 

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Ceconi, C. Can we distinguish clinically hibernation from stunning and does it matter?. Basic Res Cardiol 92 (Suppl 2), 12–15 (1997). https://doi.org/10.1007/BF00797197

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