Effect of encephalectomy on corticosterone content in the fetal rat adrenals

  • E. V. Proshlyakova
Experimental Biology


The functional state of the pituitary-adrenal system was studied after removal of the hypothalamus from rat fetuses (encephalectomy in utero). Hormonal activity of the adrenal glands was estimated by fluorometric determination of their corticosterone content. Removal of the hypothalamus in fetuses aged 18.5–19.5 days lowered the adrenal corticosterone level. Injection of a homogenate of the hypothalamus into the fetuses immediately after encephalectomy prevented this decrease. The results confirm the presence of a functional link between the hypothalamus and the pituitary-adrenal system in rat fetuses.

Key Words

rat fetuses hypothalamus adrenals corticosterone 

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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • E. V. Proshlyakova

There are no affiliations available

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