Abstract
A cross-reacting (CR) antigen, group A streptococcal polysaccharide and antigen of mammalian thymus and skin, was studied. The CR antigen was found in all adult human and embryonic tissues regardless of blood group, in all animals of different species studied, and in the tissues of rabbits immunized with streptococci and producing antibodies against A-polysaccharide. The results indicate that antibodies developing against the CR-determinant of A-polysaccharide and epithelial tissues belong to the class of autoantibodies. The reaction of these autoantibodies with the CR antigen is probably one cause of the development of autoimmune thymitis in rheumatic fever.
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Lyampert, I.M., Beletskaya, L.V., Borodiyuk, N.A. et al. Autoantibodies against the common antigenic determinant of group a streptococcal polysaccharide and epithelial cells of mammalian thymus and skin. Bull Exp Biol Med 81, 712–715 (1976). https://doi.org/10.1007/BF00797140
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DOI: https://doi.org/10.1007/BF00797140