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Model of a chronic cholera vibrio carrier state in germ-free rats

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Germ-free or monofloral (contaminated with a nonpathogenic spore-bearing bacillus), and ordinary albino rats of the OFA strain were infected withVibrio cholerae El-Tor of the “Ogawa” and “Inaba” serotypes (6·109 bacterial cells in 1.5 ml physiological saline per rat). Approximately 1 week after infection the number of vibrios reached hundreds of millions per gram feces, and it remained at this level for over 100 days (period of observation). Newborn rats were infected naturally from the adult vibrio carriers and themselves became vibrio carriers. The number of vibrios excreted by animals which were germ-free and monofloral before infection was approximately the same. The cholera vibrios in the intestinal tract of ordinary (control) rats completely died and none were ever found in the feces.

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Literature Cited

  1. O. V. Baroyan, Recent Data on the Epidemiology and Prophylaxis of El-Tor Cholera [in Russian], Moscow (1967).

  2. O. V. Baroyan, El-Tor Cholera [in Russian], Moscow (1971).

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  10. C. E. Miller and R. B. Sack, in: Advances in Germ-Free Research and Gnotobiology (International Symposium) (ed. by M. Miyakawa and T. D. Luckey), Cleveland, Ohio (1968), p. 302.

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Authors and Affiliations

  1. Academy of Medical Sciences of the USSR, USSR

    O. V. Baroyan

Authors
  1. O. V. Baroyan
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  2. O. V. Chakhava
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  3. I. N. Gailonskaya
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  4. N. Yu. Abrikosova
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  5. N. I. Blinova
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  6. N. M. Shustrova
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Additional information

N. F. Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 5, pp. 561–564, May, 1976.

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Baroyan, O.V., Chakhava, O.V., Gailonskaya, I.N. et al. Model of a chronic cholera vibrio carrier state in germ-free rats. Bull Exp Biol Med 81, 701–703 (1976). https://doi.org/10.1007/BF00797136

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  • DOI: https://doi.org/10.1007/BF00797136

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