Abstract
The ability of rats to relearn the direction of the avoidance response was studied in a U-shaped maze. Four training series of experiments were carried out, each with a different direction (to right or left) of running. In small and average doses (0.5 and 2 mg/kg) amphetamine shortened the latent periods of the responses and had no effect on the animals ability to relearn. A large dose of amphetamine (5 mg/kg) shortened the latent period of response but, at the same time, impaired relearning of the direction of the avoidance response, and this correlated with the strengthening of spatial preference. Caffeine, in doses of 25 and 50 mg/kg, did not affect the rats' ability to relearn.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
É. B. Arushanyan, Farmakol. Toksikol., No. 1, 111 (1975).
Yu. A. Belozertsev, in: Pharmacy in Transbaikalia [in Russian], No. 2, Chita (1972), pp. 201–203.
E. L. Shchelkunov, Zh. Vyssh. Nerv. Deyat., No. 1, 173 (1962).
C. Castellano, M. Sansome, P. Renzi, et al., Pharmacol. Res. Commun.,5, 287 (1973).
S. D. Glick, Neuropharmacology,12, 43 (1973).
H. Lal, Psychopharmacologia,14, 33 (1969).
M. Potegal, J. Comp. Physiol. Psychol.,69, 756 (1969).
Rights and permissions
About this article
Cite this article
Baturin, V.A. Effect of psychostimulants on rats relearning the direction of avoidance in a U-shaped maze. Bull Exp Biol Med 81, 692–694 (1976). https://doi.org/10.1007/BF00797132
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00797132