Effect of extremal stimulation on brain level of cyclic AMP

  • É. A. Migas
Biochemistry and Biophysics


The content of cyclic adenosine-3′,5′-monophosphate (cAMP) in the brain was investigated after electrical stimulation of immobilized rats, leading to the development of degenerative lesions in the internal organs. A marked decrease was found in the cAMP content in the rats' brain, which appeared 15 min after the beginning of extremal stimulation and remained at the same level during stimulation for 3 h. The lowering of the cAMP level was evidently connected with a deficiency of noradrenalin and, perhaps, of other biologically active amines also in the brain during electrical stimulation.

Key Words

rat brain cyclic AMP electrical stimulation degeneration of organs 


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Copyright information

© Plenum Publishing Corporation 1976

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  • É. A. Migas

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