Effect of extremal stimulation on brain level of cyclic AMP
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The content of cyclic adenosine-3′,5′-monophosphate (cAMP) in the brain was investigated after electrical stimulation of immobilized rats, leading to the development of degenerative lesions in the internal organs. A marked decrease was found in the cAMP content in the rats' brain, which appeared 15 min after the beginning of extremal stimulation and remained at the same level during stimulation for 3 h. The lowering of the cAMP level was evidently connected with a deficiency of noradrenalin and, perhaps, of other biologically active amines also in the brain during electrical stimulation.
Key Wordsrat brain cyclic AMP electrical stimulation degeneration of organs
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- 1.S. V. Anichkov, I. S. Zavodskaya, E. V. Moreva, et al., Neurogenic Degenerative Lesions and Their Pharmacotherapy [in Russian], Leningrad (1969).Google Scholar
- 2.O. N. Zabrodin, Transactions of the Institute of Experimental Medicine, Academy of Medical Sciences of the USSR [in Russian], Vol. 7–8, Parts 1–3, Leningrad (1963), pp. 212–214.Google Scholar
- 3.E. V. Moreva, Farmakol. Toksikol., No. 6, 661 (1967).Google Scholar
- 4.B. Breckenridge, Proc. Nat. Acad. Sci. USA,52, 1580 (1964).Google Scholar
- 5.M. Goldberg, J. Larner, H. Sasko, et al., Analyt. Biochem.,28, 523 (1969).Google Scholar
- 6.W. Lamprecht and I. Trautschold, in: Methoden der enzymatischen Analyse (ed. by H. Bergmeyer), Weinheim (1962), p. 543.Google Scholar
- 7.O. Rosen and S. Rosen, Res. Commun. Chem. Path. Pharmacol.,31, 82 (1968).Google Scholar
- 8.M. Slein, in: Methoden der enzymatischen Analyse (ed. by H. Bergmeyer), Weinheim (1962), p. 117.Google Scholar