Abstract
An electron-microscopic investigation was made of allografts and xenografts of the aortic valves after various methods of chemical sterilization and γ-ray irradiation. Changes in the ultrastructural components were demonstrated in the cells of the valve grafts after chemical methods of sterilization, but the cells were intact after γ-ray irradiation. The dynamics of development of specific degeneration of the connective tissue of the valves during prolonged functioning of the grafts in the human heart was revealed. Degeneration of the collagen was shown not to be connected with its enzymic destruction, but to be the result of passive mechanical injury.
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Yaroshinskii, Y.N., Shekhter, A.B., Artyukhina, T.V. et al. Electron-microscopic investigation of allografts and xenografts of the aortic valves after prolonged functioning in the human heart. Bull Exp Biol Med 78, 1084–1086 (1974). https://doi.org/10.1007/BF00796676
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DOI: https://doi.org/10.1007/BF00796676