Abstract
The duration of periods of the cell cycle and the size of the proliferative pool were studied by autoradiography with thymidine-H3 in cartilage cells of the fibula in 12-day mouse embryos homozygous for the mutant gene brachypodism-H (bpH). The total duration of the cycle in cartilage cells of bpH/bpH embryos was 4 h longer than normally, largely on account of an increase in the combined duration of the G1- and M-phases. The S-phase also was increased in the mutants, but not significantly (by 45 min). The proliferative pool of cartilage cells was greater in bpH/bpH than in +/+ embryos.
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Malinina, N.A. Effect of the brachypodism-H gene on parameters of the cell cycle in cartilage cells of the primitive mouse embryonic fibula. Bull Exp Biol Med 78, 1077–1078 (1974). https://doi.org/10.1007/BF00796674
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DOI: https://doi.org/10.1007/BF00796674