Abstract
Antitumor vaccines were obtained with the aid of a filtrate of the culture fluid after growth of a culture ofBacillus mesentericus AB-56 from the cells of a sarcoma K-239 induced by methylcholanthrene and of an undifferentiated sarcoma Rt induced by an extract of the plantRubia tinctorum. Immunization of inbred CBA mice and CBAxC57BL/j hybrids with the vaccines led to resistance to subsequent inoculation with the same tumors in 84–100% of cases. The effectiveness of vaccination depended on the time elapsing since the vaccine was prepared and on the quantity of vaccine material taken for testing postvaccinal immunity.
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Zatula, D.G. Prophylaxis of tumors induced by carcinogens in inbred mice. Bull Exp Biol Med 78, 1059–1060 (1974). https://doi.org/10.1007/BF00796667
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DOI: https://doi.org/10.1007/BF00796667