Bulletin of Experimental Biology and Medicine

, Volume 78, Issue 3, pp 1044–1046 | Cite as

Role of peripheral blood lymphocytes in experimental allergic (Pertussis) encephalomyelitis

  • A. Kh. Kanchurin
  • A. A. Babakhin
  • V. B. Gervazieva
Microbiology and Immunology
  • 14 Downloads

Abstract

Peripheral blood lymphocytes of guinea pigs with experimental allergic encephalomyelitis (EAE) induced by a single injection of an oily suspension ofBordetellapertussis cells, when cultured with heterologous brain antigen undergo blast transformation, which is most marked on the 14th–21st day after sensitization. With the development of clinical symptoms of EAE the level of blast transformation of the lymphocytes fell and reached its minimum on the 40th day. It is postulated that this may be connected with the development of transient hypersensitivity and dissemination of sensitized lymphocytes into the CNS, leading to its injury.

Key Words

allergic encephalomyelitis lymphocytes blast transformation 

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Literature Cited

  1. 1.
    A. D. Ado and A. Kh. Kanchurin, Allergie Asthmaforsch.,4, 121 (1961).Google Scholar
  2. 2.
    V. B. Gervazieva, Byull. Éksperim. Biol. i Med., No. 2, 55 (1973).Google Scholar
  3. 3.
    M. M. Zotina and Zh. G. Umerov, Abstracts of Proceedings of the Fourth All-Union Conference on Immunopathology [in Russian], Leningrad (1973), p. 76.Google Scholar
  4. 4.
    A. Kh. Kanchurin, Vestn. Akad. Med. Nauk SSSR, No. 4, 42 (1963).Google Scholar
  5. 5.
    A. Kh. Kanchurin, M. Ya. Volynskii, and M. E. Kapitonova, Excerpta Med. (Amsterdam),144, 49 (1967).Google Scholar
  6. 6.
    A. Kh. Kanchurin and V. B. Gervazieva, Pat. Fiziol., No. 4, 36 (1972).Google Scholar
  7. 7.
    A. Kh. Kanchurin and M. E. Kapitonova, Ann. Inst. Pasteur,177, 378 (1969).Google Scholar
  8. 8.
    A. Kh. Kanchurin and M. E. Kapitonova, Byull. Éksperim. Biol. i Med., No. 9, 73 (1971).Google Scholar
  9. 9.
    A. Bergstrand and B. Källen, Acta Path. Microbiol. Scand.,79, 551 (1971).Google Scholar
  10. 10.
    A. Bergstrand and B. Källen, Immunochemistry,10, 4 (1973).Google Scholar
  11. 11.
    J. David and P. Paterson, J. Exp. Med.,122, 1161 (1965).Google Scholar
  12. 12.
    D. Hughes, E. A. Caspary, and E. J. Fild, Z. Immun.-Forsch.,141, 14 (1970).Google Scholar
  13. 13.
    J. Munoz, J. Immunol.,86, 6 (1961).Google Scholar
  14. 14.
    R. M. Olisher and H. Meyer-Rienecker, Dtsch. Gesund.-Wes.,26, 985 (1971).Google Scholar
  15. 15.
    J. Pekarek, A. Veprecova, and S. Doutlik, Z. Immun.-Forsch.,143, 139 (1972).Google Scholar
  16. 16.
    M. Søberg, Acta Med. Scand.,184, 459 (1968).Google Scholar
  17. 17.
    H. Warnatz, F. Scheiffarth, and H. Kuntz, J. Neuropath. Exp. Neurol.,29, 575 (1970).Google Scholar
  18. 18.
    M. Wender and M. Najdowski, Biologia (Bratislava),27, 711 (1972).Google Scholar

Copyright information

© Plenum Publishing Corporation 1973

Authors and Affiliations

  • A. Kh. Kanchurin
  • A. A. Babakhin
  • V. B. Gervazieva

There are no affiliations available

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