Abstract
Experiments on waking dogs and dogs anesthetized by intravenous injection of chloralose (60–80 mg/kg) showed that chloralose has practically no effect on most indices of the oxygen transport function of the blood and produces only a very slight decrease in the oxygen saturation of the arterial blood and the minute oxygen transport by the arterial blood. The O2 consumption is reduced by a greater degree; the balance between the O2 supplied by the blood and its consumption by the tissues of the body is thereby unaffected. The results indicate that chloralose, given in the dose usually used experimentally, does not give rise to any manifestations of oxygen insufficiency such as are frequently observed when other general anesthetics are given.
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Seredenko, M.M., Il'chevich, N.V. & Bershtein, S.A. Effect of chloralose anesthesia on the oxygen transport function of the blood. Bull Exp Biol Med 78, 1031–1033 (1974). https://doi.org/10.1007/BF00796659
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DOI: https://doi.org/10.1007/BF00796659