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A study of the ingestive function of the reticuloendothelial system after administration of extracts of burned skin

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments on noninbred albino rats showed that burn trauma induced a lasting inhibition of the ingestive function of the reticuloendothelial system (RES). This was expressed as lengthening of the time of ingestion and an increase in the percentage retention of radioactive gold Au198 previously injected into the bloodstream. The slowing of the rate of Au198 uptake from the bloodstream indicated blocking of the RES, which persisted for 7 days. Extracts of burned skin act on the ingestive function of the RES like burn trauma. The results confirm the view that the focus of thermal injury is the point of origin of burn toxemia. The depression of the ingestive activity of the reticuloendothelial cells of the liver under the influence of extracts of burned skin is a sensitive indicator of the state of the nonspecific immunologic resistance of the burned organism.

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Authors and Affiliations

  1. Academy of Medical Sciences of the USSR, USSR

    N. A. Fedorov & R. V. Nedoshivina

Authors
  1. N. A. Fedorov
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  2. R. V. Nedoshivina
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  3. B. E. Movshev
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Fedorov, N.A., Nedoshivina, R.V. & Movshev, B.E. A study of the ingestive function of the reticuloendothelial system after administration of extracts of burned skin. Bull Exp Biol Med 78, 987–989 (1974). https://doi.org/10.1007/BF00796643

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  • DOI: https://doi.org/10.1007/BF00796643

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