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A method of production of cirrhosis of the liver with splenomegaly and ascites in rabbits by means of carbon tetrachloride

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Summary

To prevent an early death of animals with artificially induced cirrhosis of the liver it is suggested that carbon tetrachloride should be administered not continuously, as is usually done, but in separate courses, interrupted by periods free of injections. The protein fractions of the blood are periodically determined and biopsy is performed to control the condition of the liver. Cirrhosis of the liver, in a number of cases accompanied by ascitis and splenomegaly, develops in all the animals in 7 to 8 months.

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Literature Cited

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Authors and Affiliations

  1. Division of Pathomorphology of the A. V. Vishnevskii Institute of Surgery of the AMN SSSR, Moscow

    L. S. Rubetskoi & R. N. Korotkina

  2. Biochemical Laboratory of the A. V. Vishnevskii Institute of Surgery of the AMN SSSR, Moscow

    L. S. Rubetskoi & R. N. Korotkina

Authors
  1. L. S. Rubetskoi
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  2. R. N. Korotkina
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Rubetskoi, L.S., Korotkina, R.N. A method of production of cirrhosis of the liver with splenomegaly and ascites in rabbits by means of carbon tetrachloride. Bull Exp Biol Med 50, 757–758 (1961). https://doi.org/10.1007/BF00796058

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  • DOI: https://doi.org/10.1007/BF00796058

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