Innervation of rabbit viral papilloma

Summary

Innervation of viral papilloma was studied in rabbits. The nerves were stained by the Campos method. The viral papilloma of rabbits was found to be innervated. The nerve elements were revealed in 10 days, 1, 2, 5, 7, 14, and 16 months after the inoculation of papilloma virus. The nervous formations observed at the early dates after the virus inoculation could be considered as normal; later, an active growth of the nerve elements occured, manifested both in the changed character of the nerve fibers themselves, and in the appearance of growth bulbs at their endings.

Reactive and degenerative changes were also seen in these nerve elements, the extent of which increased with the development of the viral papilloma, especially after its malignization.