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Characteristics of the transplantable carcinoma of the rat mammary gland (RMK-1)

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Spontaneous carcinoma of the rat mammary gland of unknown origin, which appeared in a normal adult female rat, was inoculated subcutaneously to other rats and, thus, a transplantable RMK-1 carcinoma of the mammary gland was obtained. At present this carcinoma passed through the 8th generation. The “take” of the tumor 79.2%. The tumor is transplanted to female and male weaning rats, grows slowly and does not metastasize. Rats with the tumor survive up to 4 months. Microscopically, the tumor represents an alveolar low-differentiated carcinoma characteristic of rats. Although the principal strain remained alveolar up to the 14th generation, in some subpassages the tumor was of cystopapillary and solid structure.

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Literature Cited

  1. E.E. Pogosyantz. Vopr. onkol.3, 233 (1957).

    Google Scholar 

  2. L.J. Dunham and H.L. Stewart, J. Nat. Cancer Inst.13, 1299 (1953).

    Google Scholar 

  3. W.F. Dunning, M.R. Curtis, and M.E. Maun, Cancer Res.5, 644 (1954).

    Google Scholar 

  4. W.R. Earle, Am. J. Cancer24, 566 (1935).

    Google Scholar 

  5. M.J. Eisen, Am. J. Cancer39, 36 (1940).

    Google Scholar 

  6. M.J. Eisen, Cancer Res.1, 457 (1941).

    Google Scholar 

  7. R.L. Noble and J.B. Cehlip, Canad. Med. Assoc. 5,44, 1 (1941).

    Google Scholar 

  8. M.R. Rivière and M. Guerin, Bull. Assoc. Franc. Etude Cancer,45, 206 (1958).

    Google Scholar 

  9. G. Roussy, M. Guerin, and P. Guerin, Bull. Assoc. Franc. Etude Cancer31, 150 (1943).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Experimental Hormonotherapy Institute Clinical Experimental Onoclogy, Akad. Med. Nauk SSSR, Moscow

    V. P. Konoplev & N. D. Lagova

Authors
  1. V. P. Konoplev
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  2. N. D. Lagova
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Konoplev, V.P., Lagova, N.D. Characteristics of the transplantable carcinoma of the rat mammary gland (RMK-1). Bull Exp Biol Med 50, 718–720 (1961). https://doi.org/10.1007/BF00796046

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  • DOI: https://doi.org/10.1007/BF00796046

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