Summary
Compensatory hyperfunction of the heart in vitium cordis, hypertension and other diseases of the circulatory system connected with the cardiac overstrain of long duration represents the main factor in preservation of normal hemodynamic indices and clinical compensation. The rate of protein synthesis in the myocardium was studied under conditions of compensatory cardiac hyperfunction provoked by experimentally induced vitium cordis. As established, rapid development of hypertrophy during the first emergency stage of compensatory hyperfunction is accompanied by an intensified rate of protein synthesis (it about doubles). In the second stage of relatively stable hyperfunction the rate of protein synthesis is normal, while at the third stage — characterized by cardiosclerosis and progressive exhaustion —it is reduced 2–2.5 times. This depression of the normal renovation process of the protein myocardial structures may bring about a change in the contractile proteins of the heart, thus playing an important role in the development of cardiosclerosis and cardiac insufficiency.
Similar content being viewed by others
Literature Cited
F.Z. Meerson, Doklady Akad. Nauk SSSR84, 401 (1952).
F.Z. Meerson, Byull. Éksp. Biol. i Med. No. 5, 26(1953).
F.Z. Meerson, Byull. Éksp. Biol. i Med. 10, 17 (1953).
F.Z. Meerson, Arkh. Patol. No. 4, 39 (1954).
F.Z. Meerson and G.V. Kobozev, Byull. Eksp. Biol. i Med. No. 5, 50 (1955).
F.Z. Meerson, Patol. Fiziol. i Éksp. Terap. No. 6, 15 (1957).
F.Z. Meerson, Byull. Éksp. Biol. i Med. No. 9, 40 (1957).
F.Z. Meerson, Abstracts of the Proceedings at the Conference on Clinical Physiology [in Russian] (Moscow, 1959) p. 51.
V.V. Parin and F. Z. Meerson, Acta cardiol.14, 1 (1950).
E.S. Benson, et al., Circulation Res.6, 122 (1958)
A. Gize, The Physiology of the Cell [in Russian] (Moscow, 1959).
K. Kako and R.J. Bing, J. Clin. Invest.37, 465 (1958)
J.T. Wearn, Harvey Lectures (1939–1940) p. 243.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Meerson, F.Z., Zayats, T.L. Changes in the intensity of protein synthesis in the myocardium during compensatory hyperfunction of the heart. Bull Exp Biol Med 50, 678–680 (1961). https://doi.org/10.1007/BF00796034
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00796034