Bulletin of Experimental Biology and Medicine

, Volume 62, Issue 4, pp 1180–1183 | Cite as

The biological activity of estriol

  • O. V. Pokrovskaya
  • N. I. Lazarev
Experimental Biology


The purpose of study was investigation of the biological action of estriol, which is considered slightly active, on the mammary gland. The experiments were made on suckling female rats, which were given injections of chorionic gonadotropin in a dose of 150 i.u. daily during a period of 15 days and, simultaneously estradiol, estron or estriol in a dose of 5 μg. It has been found that under such experimental conditions estriol causes the same degree of development of the mammary glands as do estradiol and estron. It has been inferred from these findings that estriol has a high biologic activity with regard to the mammary glands. This fact throws light on a number of paradoxical clinical phenomena.


Public Health Biologic Activity Estradiol Mammary Gland Chorionic Gonadotropin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    E. G. Vishnyakova, V. V. Vishnyakova, N. I. Murav'eva, et al., Vopr. Onkol. No. 10, 88 (1964).Google Scholar
  2. 2.
    E. A. Ird, The Importance of Follicular Cysts of the Ovary in the Development of Dyshormonal Tumors, Candidate dissertation, Moscow (1962).Google Scholar
  3. 3.
    E. I. Kvater, Hormonal Diagnosis and Treatment in Obstetrics and Gynecology [in Russian], Moscow (1961).Google Scholar
  4. 4.
    Yu. N. Korepanov, Dyshormonal Diseases of the Mammary Glands and Follicular Cysts of the Ovaries, Candidate dissertation, Moscow (1964).Google Scholar
  5. 5.
    N. I. Murav'eva and K. S. Sharoukhova, In the book: The Physiology and Pathology of the Endocrine System [in Russian], Khar'kov (1964), p. 189.Google Scholar
  6. 6.
    N. M. Drazin and M. F. Merezhinskii (Editors), Fundamentals of Endocrinology [in Russian], Minsk (1963).Google Scholar
  7. 7.
    V. L. Samoilov, Byull. Éksp. Biol., No. 1, 104 (1963).Google Scholar
  8. 8.
    T. G. Khaleeva, Probl. Éndokrinol., No. 4, 93 (1958).Google Scholar
  9. 9.
    I. A. Éskin, V. I. Kazhdan, and O. V. Svyatukhina, Probl. Éndokrinol., No. 6 (1955), p. 80.Google Scholar
  10. 10.
    T. Bersin, The Biochemistry of Hormones [Russian translation], Moscow (1964).Google Scholar
  11. 11.
    G. Birke, E. Diczfalusy, et al., In the book: Endocrine Aspects of Breast Cancer, Edinburgh (1958), p. 213.Google Scholar
  12. 12.
    J. B. Brown, Ibid. In the book: Endocrine Aspects of Breast Cancer, Edinburgh (1958), p. 197.Google Scholar
  13. 13.
    R. C. Merrill, Physiol. Rev., Vol. 38 (1958), p. 463.Google Scholar

Copyright information

© Consultants Bureau 1966

Authors and Affiliations

  • O. V. Pokrovskaya
    • 1
  • N. I. Lazarev
    • 1
  1. 1.Laboratory of Experimental Hormone Therapy, Institute of Experimental and Clinical OncologyAcademy of Medical Sciences of the USSRMoscow

Personalised recommendations