Summary
The object of study was the degree of excretion of 5-ribosyluracil (pseudouridine) in 8 healthy subjects and in 8 cancer patients before and after local x-ray irradiation. In healthy men the diurnal excretion of pseudouridine with urine is 56.0 mg on the average. In patients with lung and esophageal cancer the average amount of pseudouridine excretion with urine is close to normal, but there are large individual variations. Single local exposure to x-rays, in a dose of 100 R practically fails to influence the degree of pseudouridine excretion, while multiple local x-irradiation of cancer patients in a total dose of 1800 R leads to an increase in pseudouridine excretion with urine by 100% on the average.
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Fedorov, N.A., Bogomazov, M.Y. & Kosenko, A.S. Excretion of 5-ribosyluracil (Pseudouridine) by healthy persons and cancer patients before and after radiotherapy. Bull Exp Biol Med 62, 1174–1176 (1966). https://doi.org/10.1007/BF00795471
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DOI: https://doi.org/10.1007/BF00795471