Advertisement

Basic Research in Cardiology

, Volume 90, Issue 1, pp 23–25 | Cite as

Hibernating myocardium: a hypometabolic state for energy conservation

  • G. A. Pantely
  • J. D. Bristow
Focussed Issue: Myocardial hibernation Short-Term Hibernation: Evidence for Downregulation of Contractile Function and Metabolic Adaptation
  • 23 Downloads

Conclusions

Moderately hypoperfused myocardium in animals initiates an active process that transiently reduces regional energy consumption below that required by the reduced flow. This eliminates most metabolic abnormalities of ischemia despite ongoing hypoperfusion. These interesting early metabolic adaptations help to confirm the concept of hibernating myocardium, a hypometabolic state for energy conservation. A similar metabolic response probably can occur in human myocardium. However, the complexities of coronary disease may make it difficult to demonstrate these metabolic adaptations in chronically hypofunctioning myocardium in humans.

Key words

Myocardial ischemia myocardial metabolism 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rahimtoola SH (1985) A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulation 72 (suppl V): V-123–V-135Google Scholar
  2. 2.
    Ross J Jr (1991) Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation. Circulation 83: 1076–1083Google Scholar
  3. 3.
    Hochachka PW (1986) Defense strategies against hypoxia and hypothermia. Science 231: 234–241Google Scholar
  4. 4.
    Pantely GA, Malone SA, Rhen WS, Anselone CG, Arai A, Bristow J, Bristow JD (1990) Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia. Circ Res 67: 1481–1493Google Scholar
  5. 5.
    Arai AE, Pantely GA, Anselone CG, Bristow J, Bristow JD (1991) Active downregulation of myocardial energy requirements during prolonged moderate ischemia in swine. Circ Res 69: 1458–1469Google Scholar
  6. 6.
    Bristow JD, Arai AE, Anselone CG, Pantely GA (1991) Response to myocardial ischemia as a regulated process. Circulation 84: 2580–2587Google Scholar
  7. 7.
    Schulz R, Guth BD, Pieper K, Martin C, Heusch G (1992) Recruitment of an inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery. A model of short-term hibernation. Circ Res 70: 1282–1295Google Scholar
  8. 8.
    Schulz R, Rose J, Martin C, Brodde OE, Heusch G (1993) Development of short-term myocardial hibernation. Its limitation by the severity of ischemia and inotropic stimulation. Circulation 88: 684–695Google Scholar
  9. 9.
    Neill WA, Ingwall JS, Andrews E, Gopal MA, Klein K, Kramer M, Oxendine JM, Piotrowski ZH, Reis I (1986) Stabilization of a derangement in adenosine triphosphate metabolism during sustained, partial ischemia in the dog heart. J Am Coll Cardiol 8: 894–900Google Scholar
  10. 10.
    Vanoverschelde JJ, Wijns W, Depré C, Essamri B, Heyndrickx GR, Borgers M, Bol A, Melin JA (1993) Mechanisms of chronic regional postischemic dysfunction in humans. New insights from the study of noninfarcted collateral-dependent myocardium. Circulation 87: 1513–1523Google Scholar

Copyright information

© Steinkopff Verlag 1995

Authors and Affiliations

  • G. A. Pantely
    • 1
  • J. D. Bristow
    • 1
  1. 1.Division of Cardiology, L 462Oregon Health Sciences UniversityPortlandUSA

Personalised recommendations