Bulletin of Experimental Biology and Medicine

, Volume 49, Issue 3, pp 226–229 | Cite as

The part played by vascular spasm in disturbing the anticoagulating systems of the blood

  • E. I. Chazov
Pathological Physiology and General Pathology


The effect of the vascular spasm on the function of the anticoagulating system of the blood was studied in experiments on rabbits. Intravenous injection of thrombin solution (4g) into healthy animals did not provoke thrombosis; on the contrary, the blood lost its ability to coagulate. However the same dose of thrombin together with 0.5 ml of pituitrin resulted in the rapid formation of intravascular thrombi causing coronary thrombosis and myocardial infarction. A study was made of the extent of the possible action of the anticoagulation system in myocardial infarction which was induced by ligation of the coronary arteries. The administration of 4g of thrombin induced a repeated infarction, and thrombosis in various parts of the vascular system. It was concluded that; a) The anticoagulation system of the blood becomes disturbed during vascular spasm, so that there is an increased tendency to intraction may occur without changes in the walls of the coronary vessels only when there is spasm which causes an increase in the tendency of the blood to coagulate. Myocardial infarction itself will after the anticoagulatory system of the blood, so that intravascular thrombus formation may be induced by small doses of thrombin administered alone.


Public Health Coronary Artery Myocardial Infarction Thrombin Intravenous Injection 
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Copyright information

© Consultants Bureau Enterprises, Inc. 1960

Authors and Affiliations

  • E. I. Chazov
    • 1
  1. 1.Institute of TherapyAMN SSSRMoscow

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