Bulletin of Experimental Biology and Medicine

, Volume 56, Issue 4, pp 1102–1104 | Cite as

Experimental study of the new antituberculosis drug diambutol

  • M. A. Breger
  • A. M. Chernukh


Studies in vitro of diambutol (ethambutol), a new antituberculosis preparation, and of its analogs and homologs demonstrated that only the L-isomer of diambutol possessed high antituberculosis activity against various strains ofMycobact. tuberculosis both sensitive and resistant to the action of antituberculosis preparations.

A study of diambutol (L-form) on a model of hematogenic tuberculosis of albino mice demonstrated its high chemotherapeutic activity. Chemotherapeutic trails of the preparation being continued on other species of animals; further studies in its pharmacological properties and its effect on the macroorganism are also being made.


Public Health Experimental Study Tuberculosis Pharmacological Property Ethambutol 
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Copyright information

© Consultants Bureau Enterprises, Inc. 1964

Authors and Affiliations

  • M. A. Breger
    • 1
  • A. M. Chernukh
    • 1
  1. 1.Division of Experimental ChemotherapyInstitute of Pharmacology of Chemotherapy of the AMN SSSRMoscow

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