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Bulletin of Experimental Biology and Medicine

, Volume 56, Issue 4, pp 1102–1104 | Cite as

Experimental study of the new antituberculosis drug diambutol

  • M. A. Breger
  • A. M. Chernukh
Pharmacology
  • 12 Downloads

Summary

Studies in vitro of diambutol (ethambutol), a new antituberculosis preparation, and of its analogs and homologs demonstrated that only the L-isomer of diambutol possessed high antituberculosis activity against various strains ofMycobact. tuberculosis both sensitive and resistant to the action of antituberculosis preparations.

A study of diambutol (L-form) on a model of hematogenic tuberculosis of albino mice demonstrated its high chemotherapeutic activity. Chemotherapeutic trails of the preparation being continued on other species of animals; further studies in its pharmacological properties and its effect on the macroorganism are also being made.

Keywords

Public Health Experimental Study Tuberculosis Pharmacological Property Ethambutol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature Cited

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    A. Lutz and M. Berger, Ann. Inst. Pasteur, Vol. 103, p. 216 (1962).Google Scholar
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    J. Thomas, C. Baughn, et al., Rev. resp. Dis., Vol. 83, p. 891 (1961).Google Scholar
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    R. G. Wilkinson, R. G. Shepherd, et al., J. Am. chem. Soc., Vol. 83, p. 2212 (1961).Google Scholar

Copyright information

© Consultants Bureau Enterprises, Inc. 1964

Authors and Affiliations

  • M. A. Breger
    • 1
  • A. M. Chernukh
    • 1
  1. 1.Division of Experimental ChemotherapyInstitute of Pharmacology of Chemotherapy of the AMN SSSRMoscow

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