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Effect of paraaminobenzoic acid on cholesterol synthesis and breakdown in the liver of intact and atherosclerotic rabbits

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made of the effect of paraaminobenzoic acid (PABA) on the synthesis and disintegration of cholesterol in the liver (V. N. Kolmakov's method) in intact rabbits and in those with developed atherosclerosis. The experiments demonstrated that PABA administered in a dose of 10 mg/kg depressed cholesterol synthesis and intensified its disintegration both in intact rabbits and in animals with developed atherosclerosis.

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Literature Cited

  1. A. F. Ryzhova, Byull. éksper. biol., 12, 61 (1961).

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  2. V. N. Kolmakov, Effect of vitamin C on the development of hypercholesteremia in fasting rabbits. Author's abstract of candidate dissertation, Leningrad (1958).

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Authors and Affiliations

  1. Department of Pharmacology, Leningrad Chemo-Pharmaceutical Institute, Leningrad, USSR

    A. F. Ryzhova

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  1. A. F. Ryzhova
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Ryzhova, A.F. Effect of paraaminobenzoic acid on cholesterol synthesis and breakdown in the liver of intact and atherosclerotic rabbits. Bull Exp Biol Med 56, 1089–1091 (1963). https://doi.org/10.1007/BF00792981

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  • DOI: https://doi.org/10.1007/BF00792981

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