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The physiological regeneration of the mammalian liver

  • Experimental Biology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Sexually mature white mice, weighing 22 gms, were sacrificed every 3 hours within the 24-hour period.

Mitoses in the liver were counted in 300 fields of vision (in about 6000 cells).

The mitotic activity is very low during the period from 12:00–24:00 hours. It is increased at 3:00 hours, reaches its maximum at 6 (7.4 mitoses) and is reduced at 9:00 hours. These data demonstrate that replacement of cells in the liver occurs by mitotic division during the night and morning hours.

The rise of mitotic activity during the period from 3:00 to 9:00 hours is statistically significant.

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Authors and Affiliations

  1. Laboratory of Growth and Development of the Institute of Experimental Biology of the AMN SSSR, Moscow

    L. D. Liozner & V. F. Sidorova

Authors
  1. L. D. Liozner
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  2. V. F. Sidorova
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Liozner, L.D., Sidorova, V.F. The physiological regeneration of the mammalian liver. Bull Exp Biol Med 48, 1532–1535 (1959). https://doi.org/10.1007/BF00792751

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  • DOI: https://doi.org/10.1007/BF00792751

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