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The mechanism of immunity to tetanus toxin at early periods after active immunization

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments on white rats have established that after primary immunization with a single, relatively large dose of adsorbed tetanus toxoid the resistance of the animals to tetanus toxin develops prior to the appearance of antitoxin in the blood. However, the administration at that period of various substances, such as tetanus toxin andBac. perfringens toxoid, or cortisone, makes the animals react by rapid production of antitoxin in the blood in detectable amounts. This phenomenon is regarded as a nonspecific stimulation of the antitoxin-forming apparatus (regional lymph modes) periods after immunization and in the absence of antitoxin in the blood at the moment of toxin administration.

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Authors and Affiliations

  1. Laboratory of Infectious Pathology of the Division of General Pathology of the Institute of Normal and Pathological Physiology of the AMN SSSR, Moscow

    L. A. Pevnitskii

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  1. L. A. Pevnitskii
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Pevnitskii, L.A. The mechanism of immunity to tetanus toxin at early periods after active immunization. Bull Exp Biol Med 48, 1528–1531 (1959). https://doi.org/10.1007/BF00792750

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  • DOI: https://doi.org/10.1007/BF00792750

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