Summary
It thus follows that, in order to increase the power of cholinesterase substrates and inhibitors to react with these enzymes, great importance is attached not only to the development of a positive charge in the molecule of the compound, but also to the distance between the atom carrying the charge and the atom forming the ester bond in the molecule. In the group of esters of some organic acids and alkylaminoalcohols which were investigated, the appearance of the charge intensified this interaction only when the oxygen atom of the bond was at the same distance from the positively charged nitrogen atom as in the acetycholine molecule. With increase of this distance the appearance of the charge weakened the ability of the majority of the substances to react.
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Fruentov, N.K. The importance of the position of the quaternary nitrogen atom in the molecule of certain compounds to their ability to react with true cholinesterase and pseudocholinesterase. Bull Exp Biol Med 48, 1492–1497 (1959). https://doi.org/10.1007/BF00792742
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DOI: https://doi.org/10.1007/BF00792742