Bulletin of Experimental Biology and Medicine

, Volume 48, Issue 6, pp 1449–1453 | Cite as

Change with dose of the cardiovascular and respiratory responses to chemical stimulation of the small intestine receptors

  • B. S. Kulaev
Physiology
  • 13 Downloads

Summary

In experiments on acute cat preparations in which nicotine and acetylcholine were injected into the fluid perfusing the intestine, which retained only nervous connection with the body, the reactions induced depended only on the dose of the chemical substances. Low doses (0.01–1.0 γ) caused a slight drop in arterial pressure, and a fall in heart and respiration rates. On the other hand, large doses of 5–100 γ of these substances caused an increase in arterial blood pressure and a rise in pulse and respiration rates. The intensity of the reaction increased with increasing dose only up to a certain limit, which was not the same for the different responses; after the maximum has been reached, the blood pressure and respiration responses fall and the cardiac reaction becomes reversed, so that the heart rate falls in response to the action of nicotine upon the intestinal receptors.

Keywords

Public Health Blood Pressure Heart Rate Nicotine Small Intestine 

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Literature Cited

  1. [1]
    D. A. Kocherga, Byull. Éksptl. Biol. i Med. 39, 2, 7 (1955).Google Scholar
  2. [2]
    B. S. Kulaev, The Role of Chemoreceptors of the Pericardium in Regulation of the Circulation and Respiration In Russian, Dissertation (Moscow, 1954).Google Scholar
  3. [3]
    B. S. Kulaev, Byull. Éksptl. Biol. i Med. 45, 6, 17 (1958). See C. B. TranlationGoogle Scholar
  4. [4]
    I. M. Rodionov, Moscow University Bulletin In Russian 3, 95 (1957).Google Scholar
  5. [5]
    V. N. Chernigovskii, Afferent Systems of the Internal Organs In Russian (Kirov, 1943).Google Scholar
  6. [6]
    V. N. Chernigovskii, Recent Advances in Biology 23, 215 (1947).Google Scholar
  7. [7]
    V. N. Chernigovskii, Transactions of the VMMA (Naval Academy) 17, 305 (1949).Google Scholar
  8. [8]
    W. W. Douglas, J. R. Innes, and H. W. Kosterlitz, J. Physiol. 111 (1950), p. 215.Google Scholar
  9. [9]
    W. W. Douglas and W. Schaumann, J. Physiol. 132 (1956), p. 17.Google Scholar

Copyright information

© Consultants Bureau Enterprises, Inc. 1960

Authors and Affiliations

  • B. S. Kulaev
    • 1
  1. 1.Laboratory of General Physiology, Institute of Normal and Pathological PhysiologyAMN SSSRMoscow

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