Bulletin of Experimental Biology and Medicine

, Volume 61, Issue 1, pp 55–56 | Cite as

Influence of the sodium salt of γ-hydroxybutyric acid on inhibition of the knee reflex

  • N. A. Kruglov
  • R. I. Kvasnoi


The object of study was the influence of the sodium salt of γ-oxybutyric acid (GHBA) on the segmental inhibition of the monosynaptic reflex arc of the spinal cord. The experiments were staged on nonanesthesized spinal cats immobilized by means of decerebration. The state of the inhibition of the monosynaptic reflex arc was estimated by the degree of decrease in the amplitude of the knee-reflex during activation of the segmental inhibitory mechanisms. GHBA in a dose of 25–50 mg/kg raises the degree of inhibition of the knee-reflex. The effect of GHBA attains a maximum within from 30 to 60 min after its intravenous injection. The effect lasts 2.5–3 h.


Public Health Sodium Spinal Cord Intravenous Injection Sodium Salt 
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Copyright information

© Consultants Bureau 1966

Authors and Affiliations

  • N. A. Kruglov
    • 1
  • R. I. Kvasnoi
    • 1
  1. 1.Laboratory of Pharmacology of the Nervous System, Institute of Pharmacology and ChemotherapyAcademy of Medical Sciences USSRMoscow

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