Summary
The object of study was the influence of the sodium salt of γ-oxybutyric acid (GHBA) on the segmental inhibition of the monosynaptic reflex arc of the spinal cord. The experiments were staged on nonanesthesized spinal cats immobilized by means of decerebration. The state of the inhibition of the monosynaptic reflex arc was estimated by the degree of decrease in the amplitude of the knee-reflex during activation of the segmental inhibitory mechanisms. GHBA in a dose of 25–50 mg/kg raises the degree of inhibition of the knee-reflex. The effect of GHBA attains a maximum within from 30 to 60 min after its intravenous injection. The effect lasts 2.5–3 h.
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Literature Cited
L. A. Serebryakov, Farmakol. i Toksikol., No. 3 (1964), p. 275.
A. E. Uspenskii, Ibid., No. 5 (1964), p. 519.
D. K. Curtis et al., J. Physiol., London, Vol. 146 (1959), p. 185.
C. Edwards and S. W. Kuffler, J. Neurochem, Vol. 4 (1959), p. 19.
J. K. Hardman and T. C. Stadtman, J. Biol. Chem., Vol. 238 (1963), p. 2081.
Idem, p. 2088.
H. Laborit et al., Presse Med., Vol. 68 (1960), p. 1867.
H. Laborit et al., In the book: Neuro-Psychopharmacology, Amsterdam, Vol. 2 (1961), p. 490.
M. W. Nirenberg and N. B. Jakoby, J. Biol. Chem., Vol. 235 (1960), p. 954–960.
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Kruglov, N.A., Kvasnoi, R.I. Influence of the sodium salt of γ-hydroxybutyric acid on inhibition of the knee reflex. Bull Exp Biol Med 61, 55–56 (1966). https://doi.org/10.1007/BF00792433
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DOI: https://doi.org/10.1007/BF00792433