Bulletin of Experimental Biology and Medicine

, Volume 44, Issue 4, pp 1235–1239 | Cite as

A study of the nature of the allergy to streptococcus in rheumatism

  • E. I. Gudkova
  • P. P. Sakharov
Microbiology and Immunity


The problem was studied of the presence of adsorption of streptococcal alletgens by the leucocytes and erythrocytes of the patients with rheumatism. The method consisted of sensitization of guinea pigs at the area of arci of the isthmus faucium by washed leucocytes and erythrocytes from the peripheral blood of the patients with rheumatism, with subsequent introduction of the filtrate of old cultures of streptococci to the animals as a hooster dose.

As a result of these experiments anaphylaxis was obtained in 26 guinea pigs out of 49, while anaphylactoid reactions occurred in 12. Control experiments showed that the filtrates of old broth cultures of streptococci give the most pronounced sensitization in guinea pigs. These sensitizing substances are neutralized by the serum of these guinea pigs which had anaphylaxis after sensitization and introduction of the booster dose of streptococcal filtrate.


Public Health Control Experiment Broth Culture Booster Dose Anaphylactoid Reaction 
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Copyright information

© Consultants Bureau 1957

Authors and Affiliations

  • E. I. Gudkova
    • 1
  • P. P. Sakharov
    • 1
  1. 1.Moscow Scientific Research Institute for Ear, Nose and ThroatMoscowUSSR

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