Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 5, pp 1720–1722 | Cite as

Effect of regeneration of the spleen and bone marrow on number of hematopoietic colonies in the mouse spleen

  • G. K. Sukhova
  • T. R. Podrabinek
  • G. V. Kharlova
Experimental Biology


Two thirds of the spleen (group 1) or the bone marrow from the right tibia (group 2) was removed from sexually mature male CBA mice. On the eighth day after lethal irradiation and injection of 1·106 nucleated cells from the intact spleen the number of hematopoietic splenic colonies was counted. A significant increase in the number of colonies was observed in the animals of both experimental groups compared with the control intact mice. the authors suggest that this increase may have been caused both by the local effect of the regenerating splenic stroma and by a certain stimulating factor secreted by the regenerating hematopoietic tissue.

Key words

Regeneration of the spleen regeneration of bone marrow hematopoietic splenic colonies 


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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • G. K. Sukhova
  • T. R. Podrabinek
  • G. V. Kharlova

There are no affiliations available

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