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Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 5, pp 1715–1717 | Cite as

Changes in mitotic activity of the corneal epithelium of albino rats cooled at different times of day

  • N. B. Simon
  • S. S. Timoshin
  • S. A. Alekseenko
Experimental Biology

Abstract

The effect of moderate hypothermia on mitotic activity of the corneal epithelium of albino rats was studied. The animals were cooled to 28°C by a contact method for 1 h. Cooling was carried out in the early morning (6 a.m.), at noon, and in the evening (6 p.m.). The response of the epithelium to cooling was found to depend on the time of day. The most marked inhibition of mitotic activity (by 14 times) occurred in the afternoon, 3 h after cooling at noon. A tendency toward restoration of normal cell division was observed 6 and 12 h later. The number of mitoses was reduced 3 h after cooling in the evening, but no changes in mitotic activity were discovered 6 and 12 h later. No changes were found 3 and 6 h after cooling in the morning, but 12 h later cell division was inhibited.

Key words

Mitotic activity stress moderate hypothermia cell division circadian rhythms 

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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • N. B. Simon
  • S. S. Timoshin
  • S. A. Alekseenko

There are no affiliations available

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