Changes in mitotic activity of the corneal epithelium of albino rats cooled at different times of day
The effect of moderate hypothermia on mitotic activity of the corneal epithelium of albino rats was studied. The animals were cooled to 28°C by a contact method for 1 h. Cooling was carried out in the early morning (6 a.m.), at noon, and in the evening (6 p.m.). The response of the epithelium to cooling was found to depend on the time of day. The most marked inhibition of mitotic activity (by 14 times) occurred in the afternoon, 3 h after cooling at noon. A tendency toward restoration of normal cell division was observed 6 and 12 h later. The number of mitoses was reduced 3 h after cooling in the evening, but no changes in mitotic activity were discovered 6 and 12 h later. No changes were found 3 and 6 h after cooling in the morning, but 12 h later cell division was inhibited.
Key wordsMitotic activity stress moderate hypothermia cell division circadian rhythms
Unable to display preview. Download preview PDF.
- 1.M. G. Kolpakov, É. M. Kazin, G. G. avdeev, et al., Byull. Éksp. Biol. Med., No. 8, 91 (1974).Google Scholar
- 2.N. b. Simon, in: Proceedings of the Second Scientific Conference of the Inter-Oblast Society of Pathophysiologists of Eastern Siberia and the Far East on Mechanisms of Reactivity and Regulation of Bodily Functions and Their Disturbances [in Russian], Vol. 1, Blagoveshchensk (1974), p. 132.Google Scholar
- 3.S. S. Timoshin and S. A. Alekseenko, Byull. Éksp. Biol. Med., No. 1, 74 (1974).Google Scholar
- 4.C. P. Sigdestad and S. Lesner, J. Interdiscip. Cycle Res.,3, 39 (1972).Google Scholar
- 5.E. M. F. Tvermyr, Virchows Arch. B11, 43 (1972).Google Scholar