Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 5, pp 1709–1712 | Cite as

Changes in mitotic activity in the corneal epithelium of rats of different ages after nociceptive stimulation

  • V. S. Valvas
Experimental Biology

Abstract

The effect of nociceptive stimulation on mitotic activity in the corneal epithelium was investigated in 21-day-old rat fetuses and in rats aged 3, 4, 5, 7, 10, 15, 20, and 25 days. Mitotic activity was not significantly changed 45 min after nociceptive stimulation of the animals (amputation of one-third of the tail) in the corneal of the fetuses and day-old rats. Between the 3rd and 10th days of postnatal development reactive inhibition of mitosis in response to nociceptive stimulation was gradually formed. After 10 days this response was intensified and reached a maximum by the 25th day. Reactive inhibition of mitotic activity is connected with delayed entry of the cells into mitosis.

Key words

Corneal epithelium nociceptive stimulation mitotic index 

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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • V. S. Valvas

There are no affiliations available

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