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Investigation of the action of aflatoxin B1 in vitro andin vivo

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The direct and transplacental action of aflatoxin B1 was compared in organ cultures of embryonic lung tissue of strain A mice, BD-IX rats, and golden hamsters. It was shown to have a toxic action on the culture but no carcinogenic effect. In experiments on mice transplacental penetration of aflatoxin B1 led to an increased frequency of mammary gland tumors only in the progeny.

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Authors
  1. L. M. Shabad
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  2. T. S. Kolesnichenko
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  3. T. V. Nikonova
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Additional information

Academician of the Academy of Medical Sciences of the USSR.

Department for the Study of Carcinogenic Agents, Oncologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 11, pp. 1349–1352, November, 1976.

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Shabad, L.M., Kolesnichenko, T.S. & Nikonova, T.V. Investigation of the action of aflatoxin B1 in vitro andin vivo . Bull Exp Biol Med 82, 1687–1690 (1976). https://doi.org/10.1007/BF00790386

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  • DOI: https://doi.org/10.1007/BF00790386

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